Women of different status, profession, and principles become connected by associaton or circumstance.
Dr. Cleo Carrillo (Eula Valdez) is a famous dermatologist, whose roster of high-profile clients include beauty queen turned society empress Marilou Cobarrubias (Ruffa Gutierrez) and socialite Betchay Magbutay-Cavendish (Carmi Martin). Cleo is married to a cardiologist, Dr. Vincent Carrillo. But her success comes with zealous detractors and nasty lawsuits, something which Marilou can relate to.
Marilou is widowed by her aged and ultra-rich husband, and her daughter-in-law, Amanda dela Vega, has arranged that she gets nothing except a small condo unit and a business on the verge of bankruptcy. Now, Marilou has to learn to get by on her own, something which her cousin, Tere Villanueva (Iza Calzado), has been doing since she was young. Tere works as a nurse, and becomes particularly close to an old woman named Amelia Marcelino. Tere sees herself in the dying woman and fears that she too might end up alone since she has been traumatized by one great love, Leon. But as if fate is teasing her, Tere is assigned to watch over a patient who happens to be Leon’s wife.
Tere’s best friend, Ada Villanueva (Jennylyn Mercado) is also suffering from heartache and regret for not accepting the marriage proposal of Jonathan, the father of her child. And now Jonathan is engaged to someone else. As an Executive Producer at a television network, Ada is able to raise her son, but barely has time to personally take care of him
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